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Optimal Therapy for Methicillin-Resistant Staphylococcus aureus Pneumonia : What Is the Best Dosing Regimen?

Jordi Rello, MD, PhD; Jordi Mallol, MD, PhD
Author and Funding Information

Affiliations: Tarragona, Spain
 ,  Reus, Spain
 ,  Dr. Rello is chief of the Critical Care Department, Joan XXIII University Hospital. Dr. Mallol is Chairman of the Pharmacology Department, School of Medicine and Health Sciences, Universitat Rovira & Virgili.

Correspondence to: Jordi Rello, MD, PhD, Critical Care Department, Joan XXIII University Hospital, Carrer Mallafre Guasch 4, 43007 Tarragona, Spain; e-mail: jrello.hj23.ics@gencat.net



Chest. 2006;130(4):938-940. doi:10.1378/chest.130.4.938
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Extract

The goal of antimicrobial prescription in pneumonia is to achieve effective active drug concentrations that result in clinical cure while avoiding antibiotic-associated toxicity or emergence of resistances. Until recently, the in vitro susceptibility of microorganism was considered the reference aspect for antibiotic efficacy for pneumonia1 and defined the concept of appropriate therapy. Pinder et al2 emphasized that standard antimicrobial dosing regimens are based on research often performed decades ago and for the most part with patients who were not critically ill. At the present time, other factors and circumstances should be considered to achieve what we call appropriate, adequate, or optimal therapy for pneumonia and to determine what is the best dosing regimen for a specific patient.

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