It has become a cottage industry to diagnose “modern” diseases in historical figures who had unusual deaths, chronic illness, or physiognomy consistent with specific conditions. On the basis of extremely postmortem evaluations, Abraham Lincoln has been thought to have had Marfan syndrome,5and to the point of this editorial, the Polish-French composer, Frederick Chopin, may have had CF.6–7 Although, the diagnosis of chronic illness in the long dead is an interesting blend of medicine and history, diagnosing disease in fictional characters falls under the realm of creative imagination. As the librarian, Emily Drew, pointed out in a letter to CHEST in December 2002, in Wilde’s play, Lady Windermere was a vivacious young women, married only 2 years who never coughs or displays any other signs of illness.8 She not only appears to have excellent health, but she does not seem exceptionally prissy. Thus, it is not such a Wilde assumption that Lady Windermere most certainly does not appear to have either CF or even her eponymous syndrome. While I mourn the passing of a literary eponym, I applaud the contribution to our understanding of this disease by Ziedalski and colleagues.4 The diagnosis of CF has profound implications for medical therapy, genetic counseling, male fertility, insurance, etc. Therefore, this article would present a strong argument that all adults with bronchiectasis of unknown ideology or NTM without documented immunodeficiency should be tested for CF by sweat chloride and CFTR genetic analysis.