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Editorials |

Lung Cancer : Family History Matters

Ann G. Schwartz, PhD, MPH
Author and Funding Information

Affiliations: Detroit, MI
 ,  Dr. Schwartz is Associate Center Director, Population Sciences, Karmanos Cancer Institute and Department of Internal Medicine, Wayne State University School of Medicine.

Correspondence to: Ann G. Schwartz, PhD, MPH, Karmanos Cancer Institute, 110 E Warren Ave, Detroit, MI 48103; e-mail: schwarta@karmanos.org



Chest. 2006;130(4):936-937. doi:10.1378/chest.130.4.936
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Nitadori et al,1 in this issue of CHEST (see page 968), report an approximately twofold-increased risk of lung cancer developing in individuals with a family history of this disease (hazard ratio [HR], 1.95; 95% confidence interval [CI], 1.31 to 2.88). This prospective study of two Japanese cohorts with > 100,000 individuals allowed for the enumeration of family history before the actual lung cancer diagnosis, which minimizes recall bias. A stronger association of risk with family history was reported among women (HR, 2.65) than among men (HR, 1.69), even though only 9% of women were ever-smokers compared with 76% of men. A positive family history suggests a role for inherited susceptibility, and the gender difference by smoking exposure suggests that genetic susceptibility to lung cancer is likely to be modified by environmental exposures.

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