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The Relationship Between Migraine and Right-to-Left Shunt*: Fact or Fiction?

Martijn C. Post, MD, PhD; Werner Budts, MD, PhD
Author and Funding Information

*From the Department of Cardiology (Dr. Post), St Antonius Hospital, Nieuwegein, the Netherlands; and Department of Cardiology (Dr. Budts), Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium.

Correspondence to: Martijn C. Post, MD, PhD, Department of Cardiology, St Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, the Netherlands; e-mail: m.post@antonius.net



Chest. 2006;130(3):896-901. doi:10.1378/chest.130.3.896
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The prevalence of a right-to-left shunt, both cardiac and pulmonary, is high in patients with migraines, especially migraine with aura. Percutaneous closure of a right-to-left shunt seems to be associated with a pronounced decrease in the number of migraine attacks or its prevalence. In this review, the relationship between migraine and right-to-left shunting is described by highlighting the different pathophysiologic hypotheses.


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