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Pleural Malignant Solitary Fibrous Tumor With Sarcomatous Overgrowth Showing PDGFRβ Mutation*

Giulio Rossi, MD; Laura Schirosi, BSc; Filippo Giovanardi, MD; Giuliana Sartori, BSc; Massimiliano Paci, MD; Alberto Cavazza, MD
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*From the Section of Pathologic Anatomy (Drs. Rossi, Schirosi, and Sartori), University of Modena and Reggio Emilia, Modena, Italy; the Operative Units of Pathology (Dr. Cavazza) and Thoracic Surgery (Dr. Paci), Hospital Santa Maria Nuova, Reggio Emilia, Italy; and the Division of Oncology (Dr. Giovanardi), Civic Hospital “Ramazzini,” Carpi, Italy.

Correspondence to: Giulio Rossi, MD, University of Modena and Reggio Emilia, Section of Pathologic Anatomy, Via del Pozzo, 71, Modena 41100, Italy; e-mail: rossi.giulio@unimo.it



Chest. 2006;130(2):581-583. doi:10.1378/chest.130.2.581
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Pleural malignant solitary fibrous tumors (SFTs) are uncommon, and little is known about their histogenesis and molecular features. We report a case of pleural SFT with sarcomatous overgrowth that showed expression for PDGFRβ and a missense mutation on exon 18 of the PDGFRβ gene. The involvement of the PDGFRβ gene in SFT is compatible with a pericytic derivation, also supporting a possible role of this tyrosine kinase in malignant transformation and in the adoption of novel molecular therapies.

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