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Successful Use of Recombinant Factor VII in Massive Hemoptysis Due to Community-Acquired Pneumonia*

James A. Macdonald, MBChB; John F. Fraser, MBChB; Carole L. Foot, MBBS(Hons); Khoa Tran, MBBS
Author and Funding Information

*From Critical Care Research Group (Drs. Macdonald, Fraser, and Foot), The Prince Charles Hospital, Chermside QLD; and Department of Medicine (Dr. Tran), Logan Hospital, Meadowbrook, QLD, Australia.

Correspondence to: John F. Fraser, MBChB, Director, Critical Care Research Group, The Prince Charles Hospital, Rode Rd, Chermside, QLD, Australia; e-mail: john_fraser@health.qld.gov.au



Chest. 2006;130(2):577-579. doi:10.1378/chest.130.2.577
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Recombinant activated factor VII (rFVIIa) is a powerful hemostatic agent developed for use in hemophilia. It has been used increasingly in life-threatening hemorrhage in a variety of other settings in which conventional medical or surgical therapy is unsuccessful. This report describes the successful use of rFVIIa for pulmonary hemorrhage due to a focal bleeding source in a regional hospital where bronchial artery embolization or surgery were not available. rFVIIa may be a useful temporizing measure in the unstable patient with pulmonary hemorrhage without coagulopathic bleeding when conventional treatment is not immediately available.


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