0
Original Research: CYSTIC FIBROSIS |

Prevalence of Vertebral Fractures in Adults With Cystic Fibrosis and Their Relationship to Bone Mineral Density*

Anne Stephenson, MD; Sophie Jamal, MD; Timothy Dowdell, MD; Dawn Pearce, MD; Mary Corey, PhD; Elizabeth Tullis, MD, FCCP
Author and Funding Information

*From the Department of Respirology (Drs. Stephenson and Tullis), Adult CF Centre, the Departments of Endocrinology (Dr. Jamal) and Radiology (Drs. Dowdell and Pearce), St. Michael’s Hospital, and the Research Institute (Dr. Corey), The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Correspondence to: Anne Stephenson, MD, St. Michael’s Hospital, Respirology, 30 Bond St, 6th Floor, Bond Wing, Toronto, ON, M5B 1W8 Canada; e-mail: stephensona@smh.toronto.on.ca



Chest. 2006;130(2):539-544. doi:10.1378/chest.130.2.539
Text Size: A A A
Published online

Study objectives: The objectives of this study were to determine the prevalence of morphometric vertebral fractures in a large cohort of adult cystic fibrosis (CF) patients, and to examine the association between fractures and bone mineral density (BMD).

Design: Cross-sectional retrospective study.

Setting: A tertiary care academic hospital.

Patients: Adult CF patients who had undergone BMD testing and chest radiography within 1 month of each other.

Measurements and results: BMD was measured by dual-energy x-ray absorptiometry (DXA) at the lumbar spine (LS) and femoral neck (FN). Vertebral fractures were diagnosed using lateral chest radiographs. Several clinical and biochemical variables were assessed as correlates. Sixty subjects (36%) had z scores between −1.0 and −2.5, and 15 subjects (9%) had z scores of < −2.5. Twelve patients (7.2%) had 19 morphometric fractures. The mean BMD at the LS was 1.266 g/cm2 in the fracture group and 1.112 g/cm2 in the nonfracture group (p = 0.0002). The mean BMD at the FN was 1.129 g/cm2 in the fracture group and 0.987 g/cm2 in the nonfracture group (p = 0.0006). Both FEV1 and body mass index were significantly associated with BMD at both the LS and the FN.

Conclusion: Seven percent of adult patients with CF had vertebral fractures as determined by morphometry. Subjects in the fracture group had both clinically and statistically higher BMD as measured by DXA. Our findings raise the intriguing possibility that BMD may not be useful in identifying CF patients with fractures.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543