Despite recent predictions of impending death for closed pleural biopsy,1– Chakrabarti and colleagues (see page 1549)2– provide convincing evidence that pleural biopsy still has a pulse. The authors’ data and discussion offer several points worth reinforcing. In the setting of a diagnostically negative thoracentesis with findings consistent with an exudative effusion, closed pleural biopsy provides a 51% diagnostic sensitivity for pleural malignancy when pleural tissue is successfully obtained. This success was not directly proportional to the level of training, as has been found by others.3– A trend supporting more biopsies increasing the yield for pleural malignancy was noted; the lack of statistical significance likely represents a β error. Earlier studies of tuberculous pleuritis4– and pleural malignancy5 have shown that more closed pleural biopsy specimens increase the diagnostic yield. The current study reconfirms the limited morbidity of pleural biopsy.