0
Original Research: COPD |

Use of Peak Oxygen Consumption in Predicting Physical Function and Quality of Life in COPD Patients*

Michael J. Berry, PhD; Norman E. Adair, MD; W. Jack Rejeski, PhD
Author and Funding Information

*From the Department of Health and Exercise Science, and Section on Pulmonary and Critical Care Medicine, Department of Medicine, Wake Forest University, Winston-Salem, NC.

Correspondence to: Michael J. Berry, PhD, Department of Health and Exercise Science, PO Box 7868, Wake Forest University, Winston-Salem, NC 27109-7868; e-mail: berry@wfu.edu



Chest. 2006;129(6):1516-1522. doi:10.1378/chest.129.6.1516
Text Size: A A A
Published online

Objective: To determine whether peak oxygen consumption (V̇o2peak) adds to the power of FEV1 in predicting physical function and quality of life in COPD patients.

Design: Single-center cross-sectional study.

Methods: Subjects included 291 COPD patients who completed pulmonary function testing, a graded exercise test, a 6-min walk, and stair climb test to assess physical function; a questionnaire assessing self-reported physical function; and a disease-specific, health-related quality-of-life questionnaire. Hierarchical multiple regression analysis was used to determine the contribution of V̇o2peak in predicting physical function and quality of life after accounting for FEV1.

Results: After accounting for FEV1, V̇o2peak added significantly to the prediction of 6-min walk distance (R2 increased by 0.395 [p < 0.005]); stair climb time (R2 increased by 0.262 [p < 0.005]); self-reported function (R2 increased by 0.109 [p < 0.005]); and health-related quality-of-life domain of mastery (R2 increased by 0.044 [p < 0.005]). Only V̇o2peak was found to significantly predict the health-related quality-of-life domain of fatigue (R2 = 0.094 [p < 0.005]).

Conclusion: After controlling for FEV1, V̇o2peak adds significantly to the prediction of physical function and health-related quality-of-life domain of mastery in COPD patients. These results provide additional support for the use of V̇o2peak in the multidimensional assessment of COPD patients.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543