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Change in the BODE Index Reflects Disease Modification in COPD : Lessons From Lung Volume Reduction Surgery

Bartolome R. Celli, MD, FCCP
Author and Funding Information

Affiliations: Boston, MA
 ,  Dr. Celli is Professor of Medicine, Tufts University.

Correspondence to: Bartolome R. Celli, MD, FCCP, Caritas-St. Elizabeth’s Medical Center, Pulmonary Critical Care Division, 736 Cambridge St, Boston. MA, 02135; e-mail: bcelli@copdnet.org



Chest. 2006;129(4):835-836. doi:10.1378/chest.129.4.835
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Extract

Since the studies of Fletcher and colleagues,1 the natural history of COPD has been associated with the accelerated progressive decline of FEV1. FEV1 became the defining feature of the disease, and because it predicted mortality, health costs, and exacerbations,4 it constituted the logical target for disease-modifying interventions. Unfortunately, the diagnosis of COPD mandates that there be minimal FEV1 response to bronchodilators, thus making changes in FEV1 very difficult to achieve.


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