We hope this article will assist first-time submitters as well as those needing a refresher in the process. We also hope that future installments of this new CHEST section will assist authors with many aspects of manuscript development and medical writing such as study planning, grant writing, research, data collection and statistical review, manuscript writing and preparation, submission, peer review, and many other relevant topics. We encourage your feedback about this in future installments, as well as your ideas about topics you would like to see us address in this section. Thank you!