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Sputum Induction in Asthma

Christopher E. Brightling, PhD, FCCP
Author and Funding Information

Affiliations: Leicester, UK
 ,  Dr. Brightling is affiliated with the Institute for Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester.

Correspondence to: Christopher E. Brightling, PhD, FCCP, Department of Respiratory Medicine, University Hospitals of Leicester, Groby Rd, Leicester, LE3 9QP, UK; e-mail: ceb17@le.ac.uk



Chest. 2006;129(3):503-504. doi:10.1378/chest.129.3.503
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1Djukanovic, R, Sterk, PJ, Fahy, JV, et al (2002) Standardised methodology of sputum induction and processing.Eur Respir J Suppl37,1s-2s2Pavord, ID, Brightling, CE, Woltmann, G, et al Non-eosinophilic corticosteroid unresponsive asthma.Lancet1999;353,2213-22143Green, RH, Brightling, CE, Woltmann, GW, et al Analysis of induced sputum in adults with asthma: identification of a subgroup with neutrophilic inhaled corticosteroid resistant disease.Thorax2002;57,875-8794Gibson, PG, Simpson, JL, Saltos, N Heterogeneity of airway inflammation in persistent asthma: evidence of neutrophilic inflammation and increased sputum interleukin-8.Chest2001;119,1329-13365Green, RH, Brightling, CE, McKenna, S, et al Reduced asthma exacerbations with management strategy directed at normalising the sputum eosinophil count.Lancet2002;360,1715-17216Bacci, E, Cianchetti, S, Bartoli, M, et al Low sputum eosinophils predict the lack of response to beclomethasone in symptomatic asthmatic patients.Chest2006;129,565-5727Meijer, RJ, Postma, DS, Kauffman, HF, et al Accuracy of eosinophils and eosinophil cationic protein to predict steroid improvement in asthma.Clin Exp Allergy2002;32,1096-11038Berry, MA, Morgan, A, Green, RH, et al Clinical and pathological features of non-eosinophilic asthma: a distinct asthma phenotype associated with inhaled corticosteroid resistance [abstract].Thorax2005;60,ii49Thomson, NC, Spears, M The influence of smoking on the treatment responses in patients with asthma.Curr Opin Allergy Clin Immunol2005;5,57-6310Chalmers, GW, MacLeod, KJ, Thomson, L, et al Smoking and airway inflammation in patients with mild asthma.Chest2001;120,1917-192211Pijnenburg, MW, Bakker, EM, Hop, WC, et al Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial.Am J Respir Crit Care Med2005;172,831-83612Smith, AD, Cowan, J, Brasset, KP, et al Use of exhaled nitric oxide measurements to guide treatment in chronic asthma.N Engl J Med2005;352,2163-2173

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