0
Editorials |

Modulation of Cardiovascular Risk Factors by Obstructive Sleep Apnea

Lyle J. Olson, MD; Virend K. Somers, MD, PhD
Author and Funding Information

Affiliations: Rochester, MN
 ,  Drs. Olson and Somers are affiliated with the Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation.

Correspondence to: Lyle Olson, MD, Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905; e-mail: olson.lyle@mayo.edu



Chest. 2006;129(2):218-220. doi:10.1378/chest.129.2.218
Text Size: A A A
Published online

Extract

Cardiovascular disorders are the most common cause of morbidity and mortality in the Western World.1 Obstructive sleep apnea (OSA), which is estimated to affect > 15 million people in the United States, is also highly prevalent.2 Large, cross-sectional epidemiologic studies3 have demonstrated an association between OSA and the risk for hypertension, stroke, congestive heart failure, and coronary artery disease. However, confounding factors have made it difficult to definitively establish causal relationships, with the exception of systemic hypertension.4 Available studies have suggested that OSA is a risk factor for coronary artery disease, although the level of risk appears to be low. In the Sleep Heart Health study cohort,5 the odds ratio for coronary artery disease in the highest apnea-hypopnea index (AHI) quartile (AHI, > 11) was 1.27 compared to that in the lowest quartile (AHI, < 1.4). On the other hand, observational studies6 have suggested a significant increase in ischemic cardiac events in patients with untreated severe OSA, compared to those receiving treatment with continuous positive airway pressure (CPAP).

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
Guidelines
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543