The format of this clinical practice guideline is as follows. It begins with an executive summary of the clinical recommendations. This is followed by an extensive review of the literature, divided into sections, that contains diagnostic and therapeutic recommendations; recommendations are repeated verbatim in the “Summary of Recommendations” at the end of each section. The concluding sections provide (1) a collation of anticipated therapeutics that are currently in clinical trials or under consideration for approval for future treatment and (2) an array of proposed topics for future research in areas in which there is currently a dearth of evidence. The strength of recommendations grading system is described in detail in the section on “Methodology.” Briefly, the grading of the strength of recommendations is based on both the quality of the evidence and the net benefit of the diagnostic or therapeutic procedure. In the descriptions of methods in each section, there is a wide variety of start dates for the various literature searches. Many of the searches begin with the early MEDLINE or PubMed conception, but other dates were selected based on the author’s knowledge of when a particular topic first appeared in the literature or became a germane issue. By providing summaries in different formats and different contexts, the Committee hopes to meet the potential varied needs of readers who, on the one hand, might want to read a quick overview of the subject; or, on the other hand, might want to use the document as an evidenced-based reference source and for in-depth selected reading. With respect to recommendations, the Committee unanimously agreed to occasionally include a clinically important treatment that has been shown to be effective for a specific disease even when the evidence was based on a clinical outcome other than cough.