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COPD, Inflammation and Its Modulation by Phosphodiesterase 4 Inhibitors: Time to Look Beyond the FEV1

Bartolome Celli, MD, FCCP
Author and Funding Information

Affiliations: Boston, MA
 ,  Dr. Celli is Chief, Pulmonary and Critical Care Medicine, St. Elizabeth’s Medical Center.

Correspondence to: Bartolome Celli, MD, FCCP, Caritas St. Elizabeth’s Medical Center, Chief Pulmonary and Critical Care Medicine, St. Elizabeth’s Medical Center, 736 Cambridge St, Boston, MA 02135-2997; e-mail: bcelli@copdnet.org



Chest. 2006;129(1):5-6. doi:10.1378/chest.129.1.5
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The American Thoracic Society and the European Respiratory Society have redefined COPD as a preventable and treatable disease state characterized by airflow limitation that is not fully reversible. The airflow limitation is associated with an abnormal inflammatory response to inhaled particles or gases, primarily cigarette smoke. COPD also has important systemic consequences.1 This definition provides a shift from a narrow paradigm, centered solely on the degree and progression of airflow obstruction, to a broader one, providing a more optimistic view in which interventions can be envisioned at different levels of the pathogenetic mechanisms.

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