0
Articles |

Microarray Analysis of Peripheral Blood Cells in Pulmonary Arterial Hypertension, Surrogate to Biopsy*

Todd M. Bull, MD; Chris D. Coldren; Patrick Nana-Sinkam, MD; Sylk M. Sotto-Santiago; Mark Moore, BA; Norbert F. Voelkel, MD; Mark W. Geraci, MD
Author and Funding Information

*From the Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO.

Correspondence to: Todd M. Bull, MD, Pulmonary Sciences, University of Colorado, 8200 E 9th Ave, Denver, CO 80262; e-mail: todd.bull@uchsc.edu



Chest. 2005;128(6_suppl):584S. doi:10.1378/chest.128.6_suppl.584S
Text Size: A A A
Published online

Extract

Pulmonary arterial hypertension (PAH) is associated with a diverse array of diseases that result in similar histologic and clinical phenotypes. The pathogenesis of PAH is complex, and it is likely that multiple modulating genes and environmental factors are involved. Such complexity lends itself to the use of microarray technology, which allows the efficient and accurate simultaneous expression measurement of thousands of genes.

Circulating blood cells may contain disease-specific information either because of inherent genomic alterations or because of local environmental changes. Furthermore, the gene expression of immune-modulating cells may provide disease-specific information due to inflammatory and autoimmune mechanisms that are putatively involved in the pathogenesis of PAH. We hypothesized that the analysis of gene expression profiles from peripheral blood mononuclear cells would distinguish patients with PAH from healthy volunteers. We also hypothesized that a subset of these genes would distinguish patients with idiopathic PAH (IPAH) from those with PAH due to secondary causes.

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543