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Serotonin Transporter and Receptors in Various Forms of Human Pulmonary Hypertension*

Elisabeth Marcos, MD; Elie Fadel, MD; Olivier Sanchez, MD; Marc Humbert, MD; Philippe Dartevelle, MD; Gerald Simonneau, MD; Michel Hamon, MD; Serge Adnot, MD; Saadia Eddahibi, PhD
Author and Funding Information

*From INSERM U492 and Service de Physiologie Explorations Fonctionnelles (Drs. Marcos, Sanchez, Adnot, and Eddahibi), Hôpital H. Mondor, Créteil; INSERM U288 (Dr. Hamon), NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle; Faculté de Médecine Pitié-Salpêtrière, Paris; UPRES EA2705 (Drs. Fadel and Dartevelle), Service de Pneumologie, Hôpital A. Béclère, Clamart; and UPRES EA2705 (Drs. Humbert and Simonneau), Service de Chirurgie Thoracique, Vasculaire et de Transplantation Cardiopulmonaire, Hôpital Marie Lannelongue, Le Plessis Robinson, France.

Correspondence to: Saadia Eddahibi, INSERM U492, Faculté de Médecine, 8, Avenue Général Sarrail, 94010 Créteil, France; e-mail: saadia.eddahibi@creteil.inserm.fr



Chest. 2005;128(6_suppl):552S-553S. doi:10.1378/chest.128.6_suppl.552S
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Some recent studies1 have emphasized the major role of serotonin (5-hydroxytryptamine [5-HT]) in the process of pulmonary vascular remodeling. An increased risk of primary pulmonary hypertension (PPH) has been reported in patients who used appetite suppressants acting on the 5-HT transporter (5-HTT). However, the mechanism by which 5-HT affects the pulmonary vasculature is still a matter of debate. Although we previously showed that 5-HTT overexpression was associated with pulmonary vascular smooth-muscle hyperplasia in patients with PPH,2 studies in relevant animal models provided evidence that not only the 5-HTT,34 but also several 5-HT receptors, namely 5-HT-1B,5 5-HT-2A, and 5-HT-2B,6 may contribute to the pulmonary vascular remodeling process. However, the respective contributions of 5-HT receptors and the 5-HTT in human pulmonary hypertension (PH) have not been specifically examined. Moreover, another key issue is whether alterations in the serotonin signaling pathway may be a common pathogenic mechanism in various forms of PH.

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