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Serotonin Transporter Gene Polymorphism in a Cohort of German Patients With Idiopathic Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension*

Rolf Koehler, PhD; Horst Olschewski, MD; Marius Hoeper, MD; Bart Janssen, PhD; Ekkehard Grünig, MD
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*From the Institute of Human Genetics (Dr. Koehler), the Department of Cardiology (Dr. Grünig), University of Heidelberg, Heidelberg, Germany; the Department of Pneumology (Dr. Hoeper), University of Hannover, Hannover, Germany; and the Department of Pneumology (Dr. Olschewski), University of Giessen, Giessen, Germany.

Correspondence to: Bart Janssen, PhD, Institute of Human Genetics, University of Heidelberg, INF 366, 69120 Heidelberg, Germany; e-mail: bart_janssen@med.uni-heidelberg.de



Chest. 2005;128(6_suppl):619S. doi:10.1378/chest.128.6_suppl.619S
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Extract

The serotonin transporter 5-HTT is involved in pulmonary artery smooth muscle hyperplasia that leads to pulmonary hypertension. The 5-HTT gene promotor has two different allelic variants, s (short) and l (long), causing different expression levels. The ll-genotype is associated with overexpression and was found significantly more frequently in French patients with idiopathic pulmonary arterial hypertension (IPAH) compared to a control group. We investigated the frequency of the two alleles in our sporadic IPAH and chronic thromboembolic pulmonary hypertension (CTEPH) patients.

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