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Effects of Aerosol vs IV UT-15 on Prostaglandin H2 Analog-Induced Pulmonary Hypertension in Sheep*

Brett L. Sandifer, MD; Kenneth L. Brigham, MD; E. Clinton Lawrence, MD; Richard E. Parker, PhD
Author and Funding Information

*From the Center for Translational Research in the Lung and the Andrew J. McKelvey Lung Transplantation Center, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, GA.

Correspondence to: Brett L. Sandifer, MD, the Center for Translational Research in the Lung and the Andrew J. McKelvey Lung Transplantation Center, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, GA



Chest. 2005;128(6_suppl):616S. doi:10.1378/chest.128.6_suppl.616S-a
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Extract

Prostacyclins provided the first medical treatment for pulmonary hypertension that improved mortality, but these medications have systemic effects and require continuous IV or subcutaneous infusions. We compared the effects of IV vs aerosolized UT-15 (treprostinil) on pulmonary and systemic hemodynamics during acute pulmonary hypertension in a sheep model.

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