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Imaging of Angiogenesis in Inflamed Airways and Tumors: Newly Formed Blood Vessels Are Not Alike and May Be Wildly Abnormal*: Parker B. Francis Lecture

Donald M. McDonald, MD, PhD; Peter Baluk, MD, PhD
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*From the Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, CA.

Correspondence to: Donald M. McDonald, MD, Department of Anatomy, S1363, University of California, 513 Parnassus Ave, San Francisco, CA 94143-0452; e-mail: dmcd@itsa.ucsf.edu.



Chest. 2005;128(6_suppl):602S-608S. doi:10.1378/chest.128.6_suppl.602S-a
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1Pasqualini, R, Arap, W, McDonald, DM (2002) Probing the structural and molecular diversity of tumor vasculature.Trends Mol Med8,563-5712Murphy, TJ, Thurston, G, Ezaki, T, et al Endothelial cell heterogeneity in venules of mouse airways induced by polarized inflammatory stimulus.Am J Pathol1999;155,93-1033Thurston, G, Murphy, TJ, Baluk, P, et al Angiogenesis in mice with chronic airway inflammation: strain-dependent differences.Am J Pathol1998;153,1099-11124Baluk, P, Tammela, T, Ator, E, et al Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation.J Clin Invest2005;115,247-2575McDonald, DM Angiogenesis and remodeling of airway vasculature in chronic inflammation.Am J Respir Crit Care Med2001;164,S39-S456McDonald, DM, Schoeb, TR, Lindsey, JR Mycoplasma pulmonisinfections cause long-lasting potentiation of neurogenic inflammation in the respiratory tract of the rat.J Clin Invest1991;87,787-7997Ezaki, T, Baluk, P, Thurston, G, et al Time course of endothelial cell proliferation and microvascular remodeling in chronic inflammation.Am J Pathol2001;158,2043-20558Baluk, P, Lee, CG, Link, H, et al Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways.Am J Pathol2004;165,1071-10859Baffert, F, Thurston, G, Rochon-Duck, M, et al Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vessels.Circ Res2004;94,984-99210Bowden, JJ, Schoeb, TR, Lindsey, JR, et al Dexamethasone and oxytetracycline reverse the potentiation of neurogenic inflammation in airways of rats withMycoplasma pulmonisinfection.Am J Respir Crit Care Med1994;150,1391-140111Thurston, G, Maas, K, LaBarbara, A, et al Microvascular remodelling in chronic airway inflammation in mice.Clin Exp Pharmacol Physiol2000;27,836-84112Baluk, P, Hashizume, H, McDonald, DM Cellular abnormalities of blood vessels as targets in cancer.Curr Opin Genet Dev2005;15,102-11113Willett, CG, Boucher, Y, di Tomaso, E, et al Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.Nat Med2004;10,145-14714McDonald, DM, Foss, AJ Endothelial cells of tumor vessels: abnormal but not absent.Cancer Metastasis Rev2000;19,109-12015McDonald, DM, Choyke, PL Imaging of angiogenesis: from microscope to clinic.Nat Med2003;9,713-72516Inai, T, Mancuso, M, Hashizume, H, et al Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts.Am J Pathol2004;165,35-5217McDonald, DM, Baluk, P Significance of blood vessel leakiness in cancer.Cancer Res2002;62,5381-538518Kim, S, Bell, K, Mousa, SA, et al Regulation of angiogenesisin vivoby ligation of integrin α5β1 with the central cell-binding domain of fibronectin.Am J Pathol2000;156,1345-136219Magnussen, A, Kasman, IM, Norberg, S, et al Rapid access of antibodies to α5β1 integrin overexpressed on the luminal surface of tumor blood vessels.Cancer Res2005;65,2712-272120Parsons-Wingerter, P, Kasman, IM, Norberg, S, et al Uniform overexpression and rapid accessibility of α5β1 integrin on blood vessels in tumors.Am J Pathol2005;167,193-21121Jain, RK Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.Nat Med2001;7,987-98922Morikawa, S, Baluk, P, Kaidoh, T, et al Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors.Am J Pathol2002;160,985-100023Baluk, P, Morikawa, S, Haskell, A, et al Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors.Am J Pathol2003;163,1801-1815

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