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Cellular and Molecular Mechanisms of Pulmonary Hypertension Beyond Vasodilators*

Rubin M. Tuder, MD; Norbert F. Voelkel, MD; Karen A. Fagan, MD
Author and Funding Information

*From the Department of Pathology (Dr. Tucker), The Johns Hopkins University, Baltimore, MD; and the Division of Pulmonary Sciences and Critical Care Medicine (Drs. Voelkel and Fagan), University of Colorado Health Sciences Center, Denver, CO.

Correspondence to: Norbert F. Voelkel, MD, Division of Pulmonary Sciences and Critical Care Medicine, 4200 E. Ninth Ave, University of Colorado Health Sciences Center, Denver, CO 80262; e-mail norbert.voelkel@uchsc.edu.



Chest. 2005;128(6_suppl):e1S-2E. doi:10.1378/chest.128.6_suppl.e1S
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The challenge is to find a cure for severe pulmonary hypertension—nothing less. Vascular reactivity is a blessing that is not being bestowed on most of our patients. We still face the harsh reality that the diagnosis of severe pulmonary hypertension is usually a late diagnosis of an already established disease. Our treatments are based on the presumption that they work because they achieve pulmonary vasodilation, and we hope that they may affect the altered vascular cell phenotype.

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