In this issue of CHEST (see page 3246), Samsa and colleagues7present an article that essentially states that treating hospitalized CAP patients with combination therapy, although slightly more expensive from an antibiotic-related drug cost standpoint, is cost-saving overall as compared to fluoroquinolone monotherapy. As a clinician, you may ask yourself, why is this article about cost in CHEST, as opposed to a medical economics journal, and what are we meant to do about it? Ultimately, it is in CHEST because it offers an opportunity for clinicians to appraise not only the clinical benefits of a particular strategy, but the economic consequences as well. But why should clinicians learn about economic consequences of different antibiotic regimens when decisions about which antibiotics are available are typically made by hospital pharmacy and therapeutics committees? The reason is that the clinician, in the day-to-day care of patients, is the person who is best positioned to balance costs against clinical outcomes. If a study shows that a particular therapeutic regimen is less costly, yet produces equivalent or better outcomes without worrisome side effects,8 then it is the clinician’s responsibility to do something about it. In this instance, there is more than a day’s savings associated with combination therapy, which clearly drives the difference in cost. This leaves you to answer the question, “What’s in a day?” and, by extension, “Do I think I can get a day’s savings by applying the results of this study to my patients?” If you believe that you can, then you should go out and get that day. Because studies like this will continue to be published in clinical journals, it is essential for clinicians to read and understand them, working out if the study is not only internally valid but also externally valid and generalizeable to their situation, and whether the authors have addressed all other areas of concern.