In case 2, pneumothorax occurred as the result of the rupture of a cavitary nodule. The preferential sites of nodules in WG are cortical and subpleural, which favors contact between the nodules and the pleura. Hence, subpleural nodules require particular attention, especially when excavated. In our third patient, pneumothorax was discovered at the same time as pulmonary hemorrhage, an association that has not been described in previous reports. In conclusion, pneumothorax is a rare but potentially severe event in WG that reflects active disease and requires immunosuppressive therapy associated, in pyopneumothorax, with antibiotic therapy.