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Editorials |

Are COPD and Lung Cancer Two Manifestations of the Same Disease?*

Thomas L. Petty, MD, Master FCCP
Author and Funding Information

Affiliations: Snowdrift Pulmonary Conference Denver, CO
 ,  *Based on the Keynote Speech, Lovelace Respiratory Research Institute, Annual Scientific Meeting, Santa Fe, NM, October 10, 2003.

Correspondence to: Thomas L. Petty, MD, Master FCCP, Professor of Medicine, University of Colorado, 899 Logan St, Suite 203, Denver, CO 80203; e-mail: tlpdoc@aol.com



Chest. 2005;128(4):1895-1897. doi:10.1378/chest.128.4.1895
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Extract

COPD and lung cancer loom as two of our greatest challenges in pulmonary medicine. Both are smoking-related diseases that cluster in families and worsen with age. COPD and lung cancer are often related to smoking and/or various occupational exposures,12 but this remarkable association remains yet to be better studied and explained.

The pathogenesis of COPD is currently being understood through intense studies originating from many laboratories.3 Mechanisms in the pathogenesis of lung cancer are also being aggressively approached concurrently. Are these really two diseases or two manifestations of the same disease with genetic predisposition, smoking, and environmental exposures as common denominators? This commentary explores the pathogenesis of COPD and lung cancer and considers common factors in the association between these two rising killers.

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