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Clinical Investigations: CARDIOLOGY |

Association of Reduced Carbon Monoxide Diffusing Capacity With Moderate or Severe Left Ventricular Diastolic Dysfunction in Obese Persons*

Gautham Ravipati, MD; Wilbert S. Aronow, MD, FCCP; Jasdeep Sidana, MD; George P. Maguire, MD, FCCP; John A. McClung, MD; Robert N. Belkin, MD; Stuart G. Lehrman, MD
Author and Funding Information

*From the Pulmonary and Critical Care (Drs. Aronow, Sidana, Maguire, and Lehrman) and Cardiology Divisions (Drs. Ravipati, McClung, and Belkin), Department of Medicine, Westchester Medical Center, New York Medical College, Valhalla, NY.

Correspondence to: Wilbert S. Aronow, MD, FCCP, Cardiology Division, New York Medical College, Macy Pavilion, Room 138, Valhalla, NY 10595; e-mail: WSAronow@aol.com



Chest. 2005;128(3):1620-1622. doi:10.1378/chest.128.3.1620
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Study objectives: To determine the association of reduced diffusing capacity of the lung for carbon monoxide (Dlco) with moderate or severe left ventricular diastolic dysfunction (LVDD) in obese persons.

Design: We investigated the association of Dlco with LVDD in 105 patients with a mean ± SD body mass index of 49 ± 5 kg/m2. An abnormal Dlco was < 80%. LVDD was investigated by Doppler and by tissue Doppler echocardiography. The Doppler echocardiographic data were analyzed blindly without knowledge of the clinical characteristics or whether the Dlco was normal or abnormal.

Setting: A university hospital.

Patients: The 105 patients included 19 men and 86 women (mean age, 45 ± 9 years).

Results: An abnormal Dlco was present in 62 of 105 patients (59%). Moderate or severe LVDD was present in 35 of 105 patients (33%). Moderate or severe LVDD was present in 25 of 62 patients (40%) with an abnormal Dlco and in 10 of 43 patients (23%) with a normal Dlco (p < 0.05).

Conclusion: Obese patients with a decreased Dlco have an increased prevalence of moderate or severe LVDD.


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