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Sleep-Related Hypoventilation : The Evolving Role of Leptin

Charles W. Atwood, MD, FCCP
Author and Funding Information

Affiliations: Pittsburgh, PA
 ,  Dr. Atwood is Assistant Professor of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine and the Veterans Affairs Pittsburgh Healthcare System.

Correspondence to: Charles W. Atwood, MD, FCCP, Division of Pulmonary, Allergy, and Critical Care Medicine, NW628 MUH, University of Pittsburgh School of Medicine, Pittsburgh, PA; e-mail: atwoodcw@upmc.edu



Chest. 2005;128(3):1079-1081. doi:10.1378/chest.128.3.1079
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Occasionally, scientific discoveries shape our understanding of medicine and physiology in broad and multifaceted ways that have important implications across disciplines. More than 2 decades ago, the discovery of nitric oxide (NO), and its subsequently elucidated role in vascular homeostasis, was such an example. Discovery of NO has had profound effects on clinical medicine in fields as diverse as pulmonary and critical care medicine, transplantation, infectious diseases, and cardiology. Important advances in our understanding of disorders ranging from sepsis to asthma to hypertension to organ transplantation have been made in the past decade based on our growing understanding of NO function.12

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