0
Clinical Investigations: CARDIOLOGY |

Hypoxia-Inducible Factor 1α Polymorphism and Coronary Collaterals in Patients With Ischemic Heart Disease*

Jon R. Resar, MD; Ariel Roguin, MD, PhD; Jeffery Voner, PA; Khurram Nasir, MD; Thomas A. Hennebry, MB, BCh, BAO; Julie M. Miller, MD; Roxann Ingersoll; Laura M. Kasch; Gregg L. Semenza, MD, PhD
Author and Funding Information

*From the Division of Cardiology (Drs. Resar, Roguin, Nasir, Hennebry, and Miller, and Mr. Voner), Departments of Medicine and Pediatrics, McKusick-Nathans Institute of Genetic Medicine (Ms. Ingersoll and Ms. Kasch); and Institute for Cell Engineering (Dr. Semenza), The Johns Hopkins University School of Medicine, Baltimore, MD.

Correspondence to: Jon R. Resar, MD, Johns Hopkins Hospital, Blalock 524, 600 North Wolfe St, Baltimore, MD 21287; e-mail: jresar@jhmi.edu



Chest. 2005;128(2):787-791. doi:10.1378/chest.128.2.787
Text Size: A A A
Published online

Study objectives: Marked variability exists in coronary artery collaterals in patients with ischemic heart disease. Although multiple factors are thought to play a role in collateral development, the contribution of genetic factors is largely unknown. Hypoxia inducible factor 1 (HIF-1), a transcriptional activator that functions as a master regulator of oxygen homeostasis, is one possible genetic factor that could play an important role in modulating collateral development.

Design, setting, and participants: Collateral vessels were determined in 100 patients with ≥ 70% narrowing of at least one coronary artery without acute myocardial infarction or prior revascularization. DNA was genotyped for the presence of a single nucleotide (C to T) polymorphism that changes residue 582 of HIF-1α from proline to serine.

Measurements and results: The frequency of the T allele was significantly higher among patients without collaterals compared to patients with collaterals (0.188 vs 0.037, p < 0.001). In multivariate analyses, two variables affecting collateral formation were detected: two- or three-vessel coronary artery disease was a significant positive predictor (odds ratio [OR], 4.17; 95% confidence interval [CI], 1.61 to 10.8; p = 0.001), whereas the presence of HIF-1α genotype CT or TT was a negative predictor (OR, 0.19; 95% CI, 0.04 to 0.84; p = 0.03).

Conclusions: These data suggest that variations in HIF-1α genotype may influence development of coronary artery collaterals in patients with significant coronary artery disease.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
Guidelines
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543