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Laboratory and Animal Investigations |

Accuracy and Limits of Transpulmonary Dilution Methods in Estimating Extravascular Lung Water After Pneumonectomy

Antoine Roch, MD, PhD; Pierre Michelet, MD; Benoit D’journo, MD; Denis Brousse, MD; Dorothee Blayac, SSG; Dominique Lambert, MD; Jean-Pierre Auffray, MD
Author and Funding Information

Service de Réanimation Polyvalente (Drs. Roch, Michelet, Blayac, Lambert, and Auffray) and Service de Chirurgie Thoracique (Dr. D’Journo), Hôpitaux Sud; and Service de Réanimation (Dr. Brousse), Hôpital d’Instruction des Armées Laveran, Marseille, France.

Correspondence to: Antoine Roch, MD, PhD, Département d’Anesthésie Réanimation, Hôpital Sainte-Marguerite, 13274 Marseille Cedex 9, France; e-mail: Antoine.Roch@mail.ap-hm.fr



Chest. 2005;128(2):927-933. doi:10.1378/chest.128.2.927
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Study objectives: The measurement of extravascular lung water index by double indicator (EVLWIdi) or the measurement of extravascular lung water index by transpulmonary thermodilution (EVLWItt) could be useful after pneumonectomy. Since pulmonary blood flow and volume are altered after pneumonectomy, the validity of these methods is uncertain. This study has compared measurements of EVLWIdi and EVLWItt with measurement of extravascular lung water index by gravimetry (EVLWIg) in a porcine model of pulmonary edema induced after right pneumonectomy.

Design: Randomized laboratory study.

Setting: Animal research laboratory.

Subjects: Twenty-seven female pigs; mean weight, 35 ± 5 kg (± SD).

Interventions: The pigs were anesthetized, placed on mechanical ventilation, and allocated to a two-lung group (n = 10) or a right pneumonectomy group (n = 17). EVLWIdi and EVLWItt were measured at baseline, 60 min after pneumonectomy, and 60 min after IV injection of oleic acid (OA).

Measurements and results: There was a good correlation between EVLWIg and EVLWIdi values (r = 0.96, p < 0.0001 in the two-lung group; and r = 0.81, p = 0.02 in the pneumonectomy group). EVLWIdi underestimated EVLWIg in the two-lung group (− 3 mL/kg; 95% confidence interval [CI], − 7 to + 2 mL/kg) and in the pneumonectomy group (− 0.9 mL/kg; 95% CI, − 3.3 to + 1.5 mL/kg). After pneumonectomy, EVLWItt decreased in mean by 27% and increased in mean by 70% after OA acid. There was a good correlation between EVLWIg and EVLWItt values (r = 0.96, p < 0.0001 in the two-lung group; and r = 0.90, p < 0.0001 after pneumonectomy). EVLWItt slightly overestimated gravimetric value in the two-lung group (+ 1.5 mL/kg; 95% CI, − 1.5 to + 4.2 mL/kg) and largely overestimated gravimetric value after pneumonectomy (+ 5 mL/kg; 95% CI, + 3.4 to + 6.8 mL/kg).

Conclusion: Double-indicator and transpulmonary thermodilution methods could be useful in monitoring extravascular lung water index (EVLWI) after pneumonectomy, but transpulmonary thermodilution largely overestimates EVLWI.

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