0
Communications to the Editor |

Air Pollution and Pulmonary Diseases FREE TO VIEW

Ken-ichiro Inoue, MD, PhD; Hirohisa Takano, MD, PhD; Rie Yanagisawa, PhD; Toshikazu Yoshikawa, MD, PhD
Author and Funding Information

Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Correspondence to: Ken-ichiro Inoue, MD, PhD, Inhalation Toxicology Research Team, and Pathophysiology Research Team, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, 305-8506, Japan; e-mail: inoue.kenichirou@nies.go.jp



Chest. 2005;128(2):1075. doi:10.1378/chest.128.2.1075
Text Size: A A A
Published online

To the Editor:

We would like to add some comments to the review by Smith1in CHEST (October 2004) demonstrating our recent work. In the “Air Pollution” section of the article, Smith did not refer to the causal correlation between air pollution and pneumonia. Our in vivo studies3 have demonstrated that pulmonary exposure to diesel exhaust particles (DEP), a main contributor of air pollution, aggravates acute lung injury induced by intratracheal administration of bacterial endotoxin. The exaggerated lung inflammation caused by DEP is characterized by increased lung expression of intercellular adhesion molecule-1, interleukin (IL)-1β, macrophage chemoattractant protein-1, keratinocyte chemoattractant, macrophage inflammatory protein-1α, and Toll-like receptors.2The results indicate that short-term exposure to air pollution has a harmful influence on people with predisposing factors such as pulmonary infectious diseases. Ongoing study34 has clarified that residual carbonaceous nuclei of DEP rather than the extracted organic chemicals predominantly contribute to the aggravation of endotoxin-related lung injury in vivo.

More recently, we have demonstrated that short-term pulmonary exposure to quinine, a component of DEP, can induce recruitment of inflammatory cells into the lung, at least partly, through the local expression of IL-5 and eotaxin in vivo.5 Our results indicate that exposure to quinone may play a role, at least partly, in the pathogenesis of pulmonary toxicities of DEP. In the future, studies of several other components of air pollution may be needed to develop toxicology in the “Air Pollution” section.

Smith, DD (2004) Top ten list in occupational pulmonary disease.Chest126,1360-1363. [CrossRef] [PubMed]
 
Takano, H, Yanagisawa, R, Ichinose, T, et al Diesel exhaust particles enhance lung injury related to bacterial endotoxin through expression of proinflammatory cytokines, chemokines, and intercellular adhesion molecule-1.Am J Respir Crit Care Med2002;165,1329-1335. [CrossRef] [PubMed]
 
Yanagisawa, R, Takano, H, Inoue, K, et al Enhancement of acute lung injury related to bacterial endotoxin by components of diesel exhaust particles.Thorax2003;58,605-612. [CrossRef] [PubMed]
 
Inoue, K, Takano, H, Yanagisawa, R, et al Components of diesel exhaust particles differentially affect lung expression of cyclooxygenase-2 related to bacterial endotoxin.J Appl Toxicol2004;24,415-418. [CrossRef] [PubMed]
 
Hiyoshi, K, Takano, H, Inoue, K, et al Effects of a single intratracheal administration of phenanthraquinone on murine lung.J Appl Toxicol2005;25,47-51. [CrossRef] [PubMed]
 

Figures

Tables

References

Smith, DD (2004) Top ten list in occupational pulmonary disease.Chest126,1360-1363. [CrossRef] [PubMed]
 
Takano, H, Yanagisawa, R, Ichinose, T, et al Diesel exhaust particles enhance lung injury related to bacterial endotoxin through expression of proinflammatory cytokines, chemokines, and intercellular adhesion molecule-1.Am J Respir Crit Care Med2002;165,1329-1335. [CrossRef] [PubMed]
 
Yanagisawa, R, Takano, H, Inoue, K, et al Enhancement of acute lung injury related to bacterial endotoxin by components of diesel exhaust particles.Thorax2003;58,605-612. [CrossRef] [PubMed]
 
Inoue, K, Takano, H, Yanagisawa, R, et al Components of diesel exhaust particles differentially affect lung expression of cyclooxygenase-2 related to bacterial endotoxin.J Appl Toxicol2004;24,415-418. [CrossRef] [PubMed]
 
Hiyoshi, K, Takano, H, Inoue, K, et al Effects of a single intratracheal administration of phenanthraquinone on murine lung.J Appl Toxicol2005;25,47-51. [CrossRef] [PubMed]
 
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
Guidelines
Infant/toddler pulmonary function tests-2008 revision & update.
American Association for Respiratory Care | 4/3/2009
Removal of the endotracheal tube—2007 revision & update.
American Association for Respiratory Care | 8/17/2007
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543