This comprehensive book contains 29 chapters, the first of which sets the stage by detailing the underlying principles of the techniques covered in subsequent chapters. The following chapters focus on the use of marrow stromal cells as donor cells, IV transplantation of exogenous endothelial progenitor cells that incorporate into foci of neovascularization, and transplantation of fetal and neonatal cardiomyocytes into an experimental myocardial infarct model. An entire chapter focuses on describing the unique properties of human embryonic stem cells, and the establishment of a reproducible cardiomyocyte differentiating system using these cell lines. Five chapters describe the role of cardiac fibroblasts, utilization of autologous satellite cells, and strategies for using stem cells in cardiac regeneration and in myocardial infarction. Various approaches to the preparation, manipulation, and delivery of skeletal myogenic precursor cells for optimal function in the heart are described. Three chapters describe the angiogenic effects of endothelial precursor cells and methods for augmenting vascular bed neovascularization and improving cardiac function by preventing loss of hypertrophied, but otherwise viable, cardiac myocytes. Also covered is autologous endothelial cell transplantation, which delivers both the cellular substrate and the specific signaling factors necessary to effect significant and sustained myocardial revascularization in experimental models.