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Clinical Investigations: PLEURAL |

Eotaxin-3 and Interleukin-5 Pleural Fluid Levels Are Associated With Pleural Fluid Eosinophilia in Post-Coronary Artery Bypass Grafting Pleural Effusions*

Ioannis Kalomenidis, MD; Georgios T. Stathopoulos, MD; Randal Barnette, BS, RRT, RPFT; Yubiao Guo, MD; R. Stokes Peebles, MD; Timothy S. Blackwell, MD; Richard W. Light, MD, FCCP
Author and Funding Information

*From the Department of Critical Care and Pulmonary Services (Dr. Kalomenidis), Athens Medical School, Evangelismos Hospital, Athens, Greece; Department of Respiratory and Critical Care Medicine (Dr. Guo), First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China; and the Departments of Allergy, Pulmonary, and Critical Care Medicine (Drs. Stathopoulos, Peebles, Blackwell, and Light), Vanderbilt University, Nashville; and Department of Pulmonary Medicine (Mr. Barnette), St. Thomas Hospital, Nashville, TN.

Correspondence to: Ioannis Kalomenidis, MD, Department of Critical Care and Pulmonary Services, Athens Medical School, Evangelismos Hospital, 45-47 Ipsilandou Str, 10675 Athens, Greece; e-mail:jkalomenidis@hotmail.com



Chest. 2005;127(6):2094-2100. doi:10.1378/chest.127.6.2094
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Objectives: The primary aim of this study was to examine the association between pleural fluid (PF) eosinophilia, and the PF and serum levels of interleukin (IL)-5, eotaxin-2, eotaxin-3, and vascular cell adhesion molecule (VCAM)-1 in patients with post-coronary artery bypass grafting (CABG) pleural effusions.

Design: A prospective observational study.

Setting: A tertiary teaching hospital.

Patients and methods: Thirty-eight patients with post-CABG pleural effusions were recruited into the study. An effusion that contained at least 10% eosinophils was called “eosinophilic.” The PF and serum levels of the cytokines and VCAM-1 were measured using an enzyme-linked immunosorbent assay.

Results: (1) The number of PF eosinophils significantly correlated with the number of blood eosinophils. (2) PF IL-5 levels were significantly higher than the corresponding serum levels, and there was a significant correlation between the PF and serum IL-5 levels. PF IL-5 levels significantly correlated with the PF eosinophil count, and serum IL-5 levels significantly correlated with the number of blood eosinophils. (3) PF eotaxin-3 levels were significantly higher than serum levels, and PF eotaxin-3 levels significantly correlated with the PF eosinophil count. (4) PF VCAM-1 levels were significantly lower than the corresponding serum levels, and PF VCAM-1 levels were significantly higher in eosinophilic pleural effusions (EPEs) than in non-EPEs.

Conclusion: In patients with post-CABG pleural effusions, IL-5 and eotaxin-3 are produced preferentially in the pleural cavity, and they are strongly associated with PF eosinophilia.

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