0
Clinical Investigations: INTERSTITIAL LUNG DISEASE |

Quadriceps Weakness Is Related to Exercise Capacity in Idiopathic Pulmonary Fibrosis*

Osamu Nishiyama, MD; Hiroyuki Taniguchi, MD; Yasuhiro Kondoh, MD; Tomoki Kimura, MD; Tomoya Ogawa, PT; Fumiko Watanabe, PT; Shinichi Arizono, PT
Author and Funding Information

*From the Departments of Respiratory Medicine and Allergy (Drs. Nishiyama, Taniguchi, Kondoh, and Kimura) and Rehabilitation (Mr. Ogawa, Ms. Watanabe, and Mr. Arizono), Tosei General Hospital, Seto, Aichi, Japan.

Correspondence to: Osamu Nishiyama, MD, Department of Respiratory Medicine and Allergy, Tosei General Hospital, 160 Nishioiwake-cho, Seto, Aichi, 489-8642 Japan; e-mail: nishiyama_o@yahoo.co.jp



Chest. 2005;127(6):2028-2033. doi:10.1378/chest.127.6.2028
Text Size: A A A
Published online

Study objective: In COPD, it has been shown that peripheral muscle dysfunction is a factor determining exercise intolerance. We examined the hypothesis that exercise capacity of patients with idiopathic pulmonary fibrosis (IPF) is, at least in part, determined by peripheral muscle dysfunction.

Methods: Maximum oxygen uptake (V̇o2max) was evaluated in 41 consecutive patients with IPF, along with potential determinants of exercise capacity, both in the lungs and in the peripheral muscles.

Results: Patients had reduced V̇o2max (893 ± 314 mL, 46.0% predicted) and reduced quadriceps force (QF) [65% predicted]. Significant correlates of V̇o2max reduction were vital capacity (VC) [r = 0.79], total lung capacity (r = 0.64), diffusion capacity (r = 0.64), QF (r = 0.62), maximum expiratory pressure (r = 0.48), and Pao2 at rest (r = 0.33). In stepwise multiple regression analysis, VC and QF were independent predictors of V̇o2max. Furthermore, in subgroup analysis, QF was a significant contributing factor for V̇o2max in patients who discontinued exercise because of dyspnea and/or leg fatigue.

Conclusions: We conclude that QF is a predictor of exercise capacity in IPF. Measures that improve muscle function might improve exercise tolerance.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
Guidelines
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543