University Medical Center, Groningen, the Netherlands
Correspondence to: Jack J. M. Ligtenberg, MD, Intensive and Respiratory Care Unit (ICB), University Medical Center, PO Box 30.001, NL-9700 RB Groningen, the Netherlands; e-mail: firstname.lastname@example.org
We read with interest the study by Cely et al (September 2004)1 on the relationship of baseline glucose homeostasis to hyperglycemia in critically ill patients. The authors show that hyperglycemia generally is present in critical illness, and that patients with low “baseline” hemoglobin-A1c levels are less inclined to hyperglycemia than patients with higher hemoglobin-A1c levels. Furthermore, they mention that “patients with normal and abnormal baseline glucose control had similar survival rates.” We don’t think that this statement has statistical validity, considering the limited number of evaluated patients (75 patients; ICU mortality rate, 29%).
To determine the relation between blood glucose regulation and mortality, we conducted an analysis among all patients admitted to our medical ICU over a 2-year period. A total of 1,209 consecutive patients were included. ICU mortality was 19.4%. A total of 10,954 glucose measurements were obtained. Mortality was significantly lower in the group with a mean glucose level of 4.0 to 6.0 mmol/L vs the group with a mean glucose level of 6.0 to 10.0 mmol/L: 12% vs 17.6% (p = 0.03). Patients who died in the ICU (n = 235) also had significantly higher baseline glucose values than patients who left the ICU alive (n = 974): 9.0 ± 5.3 mmol/L vs 7.6 ± 4.3 mmol/L (mean ± SD). We also calculated mortality rate after classifying patients into groups based on average glucose levels during ICU admission. The mortality rate in the group with an average glucose level of 4.4 to 6.1 mmol/L (n = 300) was 12%, while mortality with an average glucose level of > 11.1 mmol/L (n = 96) was 37.5%. Maximal glucose values during hospital admission appeared to be lower in survivors than in nonsurvivors: 9.6 ± 5.2 mmol/L vs 11.7 ± 6.0 mmol/L, respectively).
Acute hyperglycemia is frequently found in stress situations.2Since it is so common, it could be explained as a physiologic adaptation. However, hyperglycemia is associated with complications, and there is increasing evidence that strict regulation of glycemia could have beneficial effects on morbidity and even mortality.3
Based on our own findings and those of others, we assume that hyperglycemia is correlated with mortality in critically ill patients. The next important step is to design and start up feasible glucose regulation protocols and study the effect of strict glucose control also in medical intensive care patients.
Become a CHEST member and receive a FREE subscription as a benefit of membership.
Individuals can purchase this article on ScienceDirect.
Individuals can purchase a subscription to the journal.
Individuals can purchase a subscription to the journal or buy individual articles.
Learn more about membership or Purchase a Full Subscription.
Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 1
Customize your page view by dragging & repositioning the boxes below.
Enter your username and email address. We'll send you a reminder to the email address on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.