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Clinical Investigations: CARDIOLOGY |

Prospective Evaluation of Nocturnal Oximetry for Detection of Sleep-Related Breathing Disturbances in Patients With Chronic Heart Failure*

Frédéric Sériès, MD; R. John Kimoff, MD; Debra Morrison, MD; Marie Helene Leblanc, MD; Mark Smilovitch, MD; Jonathan Howlett, MD; Alexander G. Logan, MD; John S. Floras, MD, Dphil; T. Douglas Bradley, MD
Author and Funding Information

*From the Centre de Recherche (Drs. Sériès and Leblanc), Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l’Université Laval, Quebec City, PQ, Canada; Respiratory Division (Drs. Kimoff and Smilovitch), McGill University Health Centre, Montreal, PQ, Canada; the Queen Elizabeth II Health Sciences Centre (Drs. Morrison and Howlett), Halifax, NS, Canada; and the Department of Medicine (Drs. Logan, Floras, and Bradley), Toronto General Hospital-University Health Network/Mount Sinai Hospital, Toronto, ON, Canada.

Correspondence to: Frédéric Sériès, MD, Centre de Pneumologie Hôpital Laval, 2725, Chemin Sainte-Foy, Sainte-Foy, PQ, Canada G1V 4G5; e-mail: frederic.series@med.ulaval.ca



Chest. 2005;127(5):1507-1514. doi:10.1378/chest.127.5.1507
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Background: Because patients with chronic heart failure (CHF) can benefit from specific treatment for coexisting obstructive and central sleep apnea (CSA), there is a need to develop accurate screening tools to identify or exclude these sleep-related breathing disturbances (SRBDs) in patients with CHF.

Objectives: To evaluate, prospectively, the diagnostic value of nocturnal home oximetry in identifying SRBD in CHF patients and in distinguishing central events from obstructive events.

Design: Blinded comparison of hospital and home oximetry, and polysomnographic nocturnal recordings

Setting: Cardiac heart failure and sleep clinics in three tertiary referral centers.

Patients: Fifty consecutive patients who were investigated for participation in the Canadian Continuous Positive Airway Pressure Trial for Congestive Heart Failure with Central Sleep Apnea and were recruited from three different centers.

Measurements and results: Patients underwent two oximetry recordings, one at home and one during a polysomnographic study. The criterion for an SRBD was the presence of > 15 apneas and hypopneas per hour of sleep during polysomnography or an oxygen desaturation index of > 10 events per hour during oximetry. The pattern of desaturation/resaturation during oximetry was also examined to distinguish obstructive events from central events. Using a 2% fall in pulse oximetric saturation as the criterion for oxygen desaturation, home oximetry had a 85% sensitivity and a 93% specificity (p < 0.001) for detecting an SRBD. However, the desaturation/resaturation pattern did not accurately distinguish between obstructive events and central events (eg, 100% sensitivity, 17% specificity for identifying CSA). The interpretation of the oximetry recording was highly consistent between scorers (p < 0.001).

Conclusions: Overnight home oximetry is a sensitive and specific tool for identifying SRBDs in patients with CHF, but not for distinguishing between obstructive and central events in such patients.

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