Sixteen of our patients were judged to be suitable for aggressive management, and 2 patients underwent surgery as the primary treatment. In Table 1 of the article by Reich and Johnson,1 case 17 was a 3-year-old child with unexplained right hilar adenopathy and middle lobe opacification. The diagnosis was established based on histology and the results of a culture of the resected middle lobe. This patient and patient 10 represent successful surgical treatment, evidenced by the absence of recurrence. Surgery was an adjunct to successful drug treatment, which was indicated by sputum conversion and radiographic improvement in cases 6, 9, 13, and 14. Each patient had localized disease, and their relative youth (mean age, 41 years) indicated a low surgical risk, which I judged to be lower than the risk of recurrence from residual disease. They had no recurrence after long-term follow-up. The title of column 8 in Table 1, “months observed since drug treatment was DC,” applied only to those individuals in whom treatment was completed. The patients in cases 7, 8, and 11 had each received ≤ 18 months of the planned 24 months of drug therapy when the data were collated. Each patient exhibited sputum conversion and radiographic improvement, and I classified them as treatment successes. I stand by the summary of successful outcomes in the 16 persons treated with intent to cure (short-term follow-up, 15 of 16 patients [94%]; long-term follow-up, 11 of 12 patients [92%]). We attributed our high success rate to the following two factors: fewer of our patients had moderate-to-far advanced disease than in compendia drawn from tertiary care settings; and none had experienced prior treatment failure. A decision to increase the dose of ethionamide stepwise may have contributed to success by reducing drug intolerance. We could not exclude the possibility that our favorable outcome reflected infection with a population of less virulent or more drug-susceptible organisms. With the advent of the newer macrolide agents, one would hope that aggressive treatment would be even more effective.