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Clinical Investigations: CYSTIC FIBROSIS |

Muscular Strength and Function in Patients With Cystic Fibrosis*

Margareta E. Sahlberg, BSc; Ulla Svantesson, PhD; Elin M. L. Magnusson Thomas, BSc; Birgitta Strandvik, MD, PhD
Author and Funding Information

*From the Department of Pediatrics (Ms. Sahlberg and Dr. Strandvik), Institute for the Health of Women and Children, the Department of Orthopedic Surgery (Dr. Svantesson and Ms. Magnusson Thomas), Institute of Occupational Therapy and Physiotherapy, Göteborg University, Göteborg, Sweden.

Correspondence to: Margareta E. Sahlberg, BSc, West Swedish CF Center, The Queen Silvia Children’s Hospital, SE-416 85 Göteborg, Sweden; e-mail: margareta.sahlberg@vgregion.se



Chest. 2005;127(5):1587-1592. doi:10.1378/chest.127.5.1587
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Background: For 20 years, physical activity has been an important component in the treatment of cystic fibrosis (CF) patients in Sweden. Data concerning physical performance in terms of muscular strength in these patients are limited

Objective: To compare muscular strength and function in patients with CF with those aspects in a healthy control group (CG).

Design: Thirty-three patients with CF (16 women) aged 16 to 35 years and 20 healthy individuals matched for age and gender were included in the study. All participants had undertaken regular physical training two to three times per week. The following tests were performed: vertical jumping ability; hand-grip strength; abdominal strength; arm/shoulder strength; quadriceps muscle strength; and a functional test of leg muscle endurance.

Results: Patients with CF showed decreased muscle strength and function compared to control subjects (women: maximal hand-grip strength in the right [p = 0.02] and the left hand [p = 0.001]; sustained hand-grip strength in the left hand [p = 0.002]; and in leg muscle endurance [p = 0.02]; men: the number of sit-ups performed within 30 s [p = 0.03]; and left leg isokinetic quadriceps strength at 180° per second [p = 0.02]). The differences were not related to pancreatic or pulmonary function. There was no significant difference between the CF group and the CG in any other test results.

Conclusions: Our study showed few differences in muscular performance between patients with CF and healthy control subjects. Both groups had regular moderate-to-high activity levels. Further studies are needed to evaluate whether the small but significant differences might be related to metabolic abnormalities in skeletal muscles in CF patients.

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