0
Communications to the Editor |

Effects of Leukotriene Receptor Antagonists on Vascular Endothelial Growth Factor Levels in Asthma FREE TO VIEW

Andrew R. L. Medford, MBChB, BSc
Author and Funding Information

Southmead Hospital, Bristol, UK

Correspondence to: Andrew R. L. Medford, MBChB, BSc, Southmead Hospital, Bristol, UK; e-mail: andrew.medford@bris.ac.uk



Chest. 2005;127(4):1460-1461. doi:10.1378/chest.127.4.1460
Text Size: A A A
Published online

To the Editor:

Kanazawa et al1 have reported an interesting reduction in airway permeability with pranlukast that correlated with a reduction in airway vascular endothelial growth factor (VEGF) levels. However, no such reduction in VEGF levels was observed in steroid-treated asthmatics. In contrast, a clinical study2 has shown a further benefit in symptoms and lung function in the combination of leukotriene receptor antagonists and inhaled steroids. It is therefore perhaps surprising that no further reduction in airway VEGF occurred with pranlukast added to the steroid-treated patients.

Other questions remain. What is the mechanism of the reduction in measured airway VEGF level in asthma? Is there a VEGF receptor up-regulation in the airway or an increase in sflt binding free VEGF? Could this reduction be secondary to cellular changes in the airway epithelium, a known source of VEGF. Are there other significant sources of VEGF in asthma?

One limitation of the VEGF enzyme-linked immunosorbent assay is its inability to measure the more cell-associated VEGF isoforms (VEGF189 and VEGF206) that still have bioactivity. Analysis of their expression would increase understanding of the changes in VEGF bioactivity in asthma.

Kanazawa, H, Yoshikawa, T, Hirata, K, et al (2004) Effects of pranlukast administration on vascular endothelial growth factor levels in asthmatic patients.Chest125,1700-1705. [CrossRef] [PubMed]
 
Virchow, J Christian, Prasse, A, Naya, I, et al Zafirlukast improves asthma control in patients receiving high-dose inhaled corticosteroids.Am J Respir Crit Care Med2000;162,578-585. [PubMed]
 

Figures

Tables

References

Kanazawa, H, Yoshikawa, T, Hirata, K, et al (2004) Effects of pranlukast administration on vascular endothelial growth factor levels in asthmatic patients.Chest125,1700-1705. [CrossRef] [PubMed]
 
Virchow, J Christian, Prasse, A, Naya, I, et al Zafirlukast improves asthma control in patients receiving high-dose inhaled corticosteroids.Am J Respir Crit Care Med2000;162,578-585. [PubMed]
 
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543