0
Opinions/Hypotheses |

Circulatory Responses to Exercise*: Are We Misreading Fick?

Thomas W. Rowland, MD
Author and Funding Information

*From the Department of Pediatrics, Baystate Medical Center, Springfield, MA.

Correspondence to: Thomas W. Rowland, MD, Department of Pediatrics, Baystate Medical Center, Springfield, MA 01199; e-mail: thomas.rowland@bhs.org



Chest. 2005;127(3):1023-1030. doi:10.1378/chest.127.3.1023
Text Size: A A A
Published online

The Fick equation holds that oxygen uptake (V̇o2) is the product of cardiac output and arterial venous oxygen difference. Factors limiting V̇o2 (ie, maximal V̇o2) with exercise have therefore been traditionally sought within the determinants of cardiac function. However, such an approach ignores a large body of research evidence indicating that peripheral factors, particularly arteriolar dilatation and skeletal muscle pump function, control circulatory responses to exercise rather than central cardiac mechanisms. Efforts to understand the limiting factors for physiologic aerobic fitness are thus more appropriately directed toward characterizing these peripheral determinants of blood flow.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
Guidelines
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543