First, we thank Drs. Luo and Ündar for their comments on our investigation, and acknowledge them for recognizing the interest and importance of our article. In answer to the first comment, we like to express that we also recognize the fact that the number of emboli (micro and macro) delivered during cardiopulmonary bypass (CPB) could have an impact on the incidence of postoperative neurologic complications. Unfortunately, we were unable to use transcranial Doppler (TCD) routinely in our patients. However, a longer CPB procedure is theoretically accompanied by a higher number of emboli delivered, as was described previously.1–2 Therefore, although we did not use TCD, one could hypothesize that the aforementioned is confirmed by our findings as presented in Table 2. However, the large difference in number of patients in our study (27 patients with postoperative neurologic complications vs 1,368 patients without neurologic complications) made the results of the analysis of variance test suspicious. That is why we used cluster analyses, and in the sequence of these analyses the impact of duration of CPB on the development of postoperative neurologic complications disappeared. Nevertheless, microremobilization of cerebral vessels during CPB could be one of the factors explaining the significance of fluctuations in hemodynamic parameters in the increased risk for the development of postoperative neurologic complications. It is well documented that good blood flow through the brain might hasten the clearance of microemboli, and increased perfusion pressure during CPB has been proposed as a means of forcing air bubbles through the cerebral microcirculation.3 It is obvious that fluctuations in perfusion pressure could often provoke the stabilization of an embolus in a cerebral vessel and increase the duration of hypoxia and extend the area of hypoxic damage.