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Pulmonary and Critical Care Pearls |

A 70-Year-Old Man With Pulmonary Infiltrates and a Positive Antineutrophil Cytoplasmic Autoantibody Test Result*

Augustine S. Lee, MD; Olaf Wiesner, MD; Delmar J. Gillespie, MD, FCCP; Thomas E. Witzig, MD; Henry Homburger, MD; Ulrich Specks, MD
Author and Funding Information

*From the Division of Pulmonary and Critical Care Medicine (Drs. Lee, Gillespie, and Specks), Thoracic Diseases Research Unit (Dr. Wiesner), Division of Hematology and Oncology (Dr. Witzig), and Division of Clinical Biochemistry and Immunology (Dr. Homburger), Mayo Clinic, Rochester, MN.

Correspondence to: Ulrich Specks, MD, Mayo Clinic, 200 First St, SW, Rochester, MN 55905; e-mail: specks.ulrich@mayo.edu



Chest. 2005;127(3):1045-1050. doi:10.1378/chest.127.3.1045
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Extract

A 70-year-old white man was referred for evaluation of pulmonary infiltrates and bronchiectases associated with cough and constitutional symptoms. He was in his usual state of health until he acquired B-cell non-Hodgkin lymphoma (NHL) in 1990. The lymphoma was localized to his stomach, and he was treated with surgical resection; chemotherapy with cyclophosphamide, vincristine, prednisone, and hydroxyurea; and radiation to the gastric bed. One year later, left lower lobe pneumonia developed that was treated with antibiotics. Because of persistent infiltrates, bronchoscopy was performed, with biopsy specimens revealing no abnormalities, and bronchiectases was diagnosed based on radiographic features.

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