We read with interest Dr. Ferrero’s comments regarding our recently published work (June 2004)1about vascular endothelial growth factor (VEGF) levels in tuberculosis patients. We disagree, however, with his conclusion that for the accurate measurement of circulating VEGF levels, measuring serum levels is completely unsuitable. Indeed, VEGF expression has been found not only in platelets, but also in activated macrophages, neutrophils, smooth muscle cells, monocytes, and T lymphocytes. However, the extent to which these cells contribute to the circulating VEGF levels in vivo, and its physiologic and pathologic relevance is not yet clear. In a recent article, Mittermayer et al2 showed that systemic plasma concentrations of VEGF are increased by inflammation that is independent from thrombin formation but is associated with neutrophil degranulation. They proposed that the activation of leukocytes rather than platelets plays a role in the marked increase in VEGF levels. In another view, activated platelets have been found to release VEGF together with β-thromboglobulin, suggesting that VEGF resides in the α-granules of the platelets.3 This finding leaves open the possibility that at least part of the VEGF in platelets has come from plasma by endocytosis.