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Editorials |

Glutathione: A Radical Treatment for Cystic Fibrosis Lung Disease?

Brian J. Day, PhD
Author and Funding Information

Affiliations: Denver, CO
 ,  Dr. Day is Associate Professor of Medicine & Pharmaceutical Sciences, National Jewish Medical & Research Center.

Correspondence to: Brian J. Day, PhD, Associate Professor of Medicine & Pharmaceutical Sciences, National Jewish Medical & Research Center, K715, 1400 Jackson St, Denver, CO, 80206; dayb@njc.org



Chest. 2005;127(1):12-14. doi:10.1378/chest.127.1.12
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In this issue of CHEST (see page 308), Bishop and colleagues report encouraging results from a small, double-blind, placebo-controlled clinical trial of inhaled glutathione in patients with cystic fibrosis. The rationale for this therapy lies in previous data reporting that glutathione levels in the lung epithelial lining fluid of patients with cystic fibrosis are low,1 and that cystic fibrosis lung disease is associated with increased oxidative damage.2 In addition, more recent studies36 have also demonstrated that the cystic fibrosis transmembrane conductance regulator (CFTR), which is defective in cystic fibrosis, regulates a substantial portion of glutathione efflux into the epithelial lining fluid.

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  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543