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Clinical Investigations: CARDIOLOGY |

Nitric Oxide Is Released Into Circulation With Whole-Body, Periodic Acceleration*

Marvin A. Sackner, MD, FCCP; Emerance Gummels, MS; Jose A. Adams, MD
Author and Funding Information

*From the Division of Pulmonary Disease and Critical Medicine (Dr. Sackner), and Department of Neonatology (Dr. Adams), Mount Sinai Medical Center, Miami Beach; and Non-Invasive Monitoring Systems, Inc. (Ms. Gummels), North Bay Village, FL.

Correspondence to: Marvin A Sackner, MD, FCCP, 300 West Rivo Alto Dr, Miami Beach, FL 33139; e-mail: Artchive@msn.com



Chest. 2005;127(1):30-39. doi:10.1378/chest.127.1.30
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Study objective: To determine if comfortably applied, whole-body, periodic acceleration releases significant amounts of nitric oxide (NO) into the circulation of healthy subjects and patients with inflammatory diseases.

Materials: Fourteen healthy adults and 40 adult patients with inflammatory diseases underwent single 45-min trials of whole-body, periodic acceleration with a new “passive exercise” device, while an ECG and a digital pulse wave were obtained with a photoelectric-plethysmograph sensor.

Methods: The position of the dicrotic notch from the pulse waveform was computed from the amplitude of the pulse divided by the height of the dicrotic notch above the end-diastolic level (a/b ratio). Increase of the a/b ratio reflects the vasodilator action of NO that causes downward movement of the dicrotic notch in the diastolic limb of the digital pulse, thereby elevating the a/b ratio.

Results: Application of whole-body, periodic acceleration was well tolerated in all participants, and all completed the 45-min treatment. The peak value of the a/b ratio markedly rose during periodic acceleration and returned to baseline during a 5-min recovery period in all healthy subjects and patients with inflammatory diseases.

Conclusions: Whole-body, periodic acceleration increased pulsatile shear stress to the endothelium leading to vasodilatation and a fall in the dicrotic notch, consistent with increased NO bioactivity in every healthy adult and adult patient with inflammatory disease so treated. Therefore, passive exercise using whole-body, periodic acceleration produces an important benefit that occurs with active exercise.

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