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Serum KL-6 and Surfactant Proteins A and D in Pediatric Interstitial Lung Disease*

Qasem A. Al-Salmi, MD; Joseph N. Walter, MD; Giuseppe N. Colasurdo, MD; Marianna M. Sockrider, MD; E. O’Brian Smith, PhD; Hiroki Takahashi, MD; Leland L. Fan, MD
Author and Funding Information

*From the Department of Pediatrics (Drs. Al-Salmi, Walter, Sockrider, Smith, and Fan), Baylor College of Medicine, Houston, TX; Department of Pediatrics (Dr. Colasurdo), University of Texas-Houston Medical School, Houston, TX; and Third Department of Internal Medicine (Dr. Takahashi), Sapporo Medical University School of Medicine, Sapporo, Japan.

Correspondence to: Leland L. Fan, MD, Texas Children’s Hospital, CC 1040.00, 6701 Fannin, Houston, TX 77030-2399; e-mail: llfan@texaschildrenshospital.org



Chest. 2005;127(1):403-407. doi:10.1378/chest.127.1.403
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Objective: To determine if serum KL-6, surfactant protein A (SP-A), and surfactant protein D (SP-D) levels are elevated in pediatric interstitial lung disease (ILD) and associated with pulmonary function and disease severity score.

Methods: Serum KL-6, SP-A, and SP-D levels were measured by enzyme-linked immunosorbent assay in 10 children with ILD and in 10 healthy volunteers. In the ILD group, FEV1 percentage of predicted, FVC percentage of predicted, and ILD disease severity score were measured and correlated with serum KL-6, SP-A, and SP-D levels.

Results: For the ILD and control groups, respectively, mean serum KL-6 was 4,523 U/mL and 206 U/mL (p = 0.007), mean serum SP-A was 133 ng/mL and 21 ng/mL (p = 0.003), and mean serum SP-D was 304 ng/mL and 75 ng/mL (p = 0.004). There was an inverse relationship between SP-A and FVC (p = 0.05), and between SP-D and FEV1 (p = 0.05). There was a direct relationship between SP-D and ILD score (p = 0.05).

Conclusions: Serum KL-6, SP-D and SP-D levels are elevated in children with ILD. SP-A and SP-D levels appear to correlate with some measures of disease severity.

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