Volume I, entitled Molecular Pathology Methods and Reviews, is broadly divided into four parts. After a general introduction (part 1), part 2 reviews lung cancer pathologic classifications, and includes examples of prototypical molecular abnormalities and gene-environment interactions that have been described for this disease. However, the meat of the volume lies in part 3, which provides detailed descriptions for laboratory approaches that are broadly categorized into subgroups comprising the various biochemical and structural cellular processes in which molecular aberrations have been described in lung cancer. For example, the “Detection of Alterations in the Cell Cycle” section includes chapters on aberrations in the RB-p16 tumor suppressor gene pathway and the detection of hypermethylated p16 alleles in sputum. Each chapter contains a brief introduction of the proposed role of that particular molecular abnormality in lung carcinogenesis, which is followed by a detailed description of methodologies for individual assays. A welcome addition to these chapters is a set of “Notes,” in which each author presents technical insights and “helpful hints” that they think are important to the successful completion or analysis of these assays. Part 4 compiles a number of different animal models that currently are in use for studying agent-specific carcinogenesis and metastasis, and for testing interventions that are designed to alter lung cancer development and progression.