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Clinical Investigations: COPD |

Polymorphisms of IL4, IL13, and ADRB2 Genes in COPD*

Ahmed E. Hegab, MSc; Tohru Sakamoto, MD; Wataru Saitoh, BS; Hosam H. Massoud, MD; Hosny M. Massoud, MD; Khalid M. Hassanein, MD; Kiyohisa Sekizawa, MD
Author and Funding Information

*From the Department of Pulmonary Medicine (Drs. Hegab, Sakamoto, Saitoh, and Sekizawa), Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan; and the Department of Chest Diseases and Tuberculosis (Drs. Massoud, Massoud, and Hassanein), Faculty of Medicine, Cairo University, Cairo, Egypt.

Correspondence to: Kiyohisa Sekizawa, MD, Department of Pulmonary Medicine, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan; e-mail: kiyo-se@md.tsukuba.ac.jp



Chest. 2004;126(6):1832-1839. doi:10.1378/chest.126.6.1832
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Study objectives: Interleukin (IL)-4, IL-13, and β2-adrenoceptor (ADRB2) are involved in airway hyperresponsiveness (AHR), and their coding genes are located on chromosome 5q31-q33. AHR is one of the risk factors for COPD. Investigating polymorphisms within these genes may help to pinpoint the genetic susceptibility to COPD.

Subjects and measurements: A case-control association study was conducted on two different ethnic groups: Japanese subjects (88 patients with COPD and 61 control subjects) and Egyptian subjects (106 patients with COPD and 72 control subjects). The following polymorphisms were genotyped: − 589 C/T, − 33 C/T, and variable number of tandem repeat (VNTR) in IL4, − 1111 C/T and + 2044 G/A in IL13, and + 46 A/G and + 79 C/G in ADRB2. Pairwise haplotype frequencies as well as genotype and allele frequencies were analyzed.

Results: The distribution of the genotype frequencies of ADRB2 + 79 C/G was significantly different between the COPD and the control groups in the Egyptians (p = 0.002). The distributions of the haplotypes in the Japanese (IL4 − 589 C/T: IL4 VNTR; IL4 − 33 C/T: IL4 VNTR) [corrected p values < 0.001 and 0.022, respectively], and those in the Egyptians (IL4 − 589 C/T: ADRB2 + 79 C/G; IL4 VNTR: ADRB2 + 79 C/G) [corrected p values, 0.033 and 0.001, respectively] showed significant differences between the COPD and the control groups.

Conclusions: The ADRB2 + 79 C/G polymorphism and the haplotypes shown in this study may be involved in the pathogenesis of COPD.


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