Bookshelf |

Therapeutic Targets in Airway Inflammation FREE TO VIEW

Michelle Harkins, MD, FCCP
Chest. 2004;126(5):1714-1715. doi:10.1378/chest.126.5.1714
Text Size: A A A
Published online


By N. Tony Eissa and David P. Huston, eds. New York, NY: Marcel Dekker, 2003; 975 pp; $225

Asthma is a complex inflammatory disease of the airways, and research over the last 20 years has outlined multiple pathways that contribute to this ongoing inflammation. Knowledge underlying the pathophysiology of asthma has recently exploded in the realms of genetics, molecular mechanisms, and cellular responses. Therapeutic Targets in Airway Inflammation, which stands out as one of the most comprehensive additions to the Lung Biology in Health and Disease series, outlines the molecular, cellular, and genetic mechanisms involved in airway inflammation, and then examines potential therapeutic options to counter the inflammatory processes observed in asthma patients.

Editors Eissa and Huston have compiled an impressive author list, numbering > 100, including many of the most well-known asthma clinicians and researchers, each addressing subjects with which they are the most expert. Unlike other volumes in this series, it is not divided into major sections. Each of the 44 chapters is well-written and includes appropriate graphs, tables, and illustrations that enhance readability, which is particularly important since the complex cellular and molecular interactions may be a bit daunting to those not already familiar with the key concepts. The text and writing styles of each respective author blend well into the overall format. As usual with this series, the chapters are well-referenced for those needing a destination for more in-depth discussion.

The first chapter, entitled “Pathophysiology of Airway Inflammation in Asthma,” provides an overview of the epidemiology of asthma, integrating genetic and environmental influences as well as information on cellular inflammation. The succeeding chapters then outline specific cells, cellular components such as proteases and peroxidases, oxidative stressors, chemokines, cytokines, and other mediators that are important in airway inflammation. Several chapters are devoted to reactive nitrogen species and to the regulation of nitric oxide and its role in inflammation. Specific attention is paid to the contributions of interleukin (IL)-4, IL-13, and IL-5, which have long been known to be important in asthma pathogenesis, and to the prospects of directed therapy against these mediators. The cytokines IL-9, IL-16, and IL-18, often less commonly discussed in the context of airway inflammation in asthma, are also covered along with the potential that they, too, may hold for asthma treatment. The last seven chapters focus on the genetics of asthma, pharmacogenetic considerations that may impact the response to therapy, and recently developed treatments directed at a variety of other targets, including immunotherapy, peptide agents, and anti-IgE.

Therapeutic Targets in Airway Inflammation is a well-written volume that covers key aspects of the cellular, molecular, and genetic components of asthma pathogenesis, along with specific therapeutic strategies aimed at these mechanisms. It accomplishes the often competing goals of being complete yet concise, and as such would appeal to clinicians and researchers who are interested in asthma pathogenesis and are looking for a reference text on airway inflammation.




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543