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Editorials |

Immunostimulation : Does It Work in COPD?

Surinder K. Jindal, MD, FCCP
Author and Funding Information

Affiliations: Chandigarh, India
 ,  Dr. Jindal is the Professor and Head, Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh.

Correspondence to: Surinder K. Jindal, MD, FCCP, Professor and Head, Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India 160012



Chest. 2004;126(5):1406-1408. doi:10.1378/chest.126.5.1406
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What constitutes immunostimulation is a matter of debate. Immunity is a highly complex mechanism with multiple functions. Activation of macrophages, enhanced antigen presentation, and increased lymphocyte responses are some of the functions of immune cells likely to promote phagocytic activity. Correction of an aberration in immunity is a function-directed rather than a general phenomenon. Immunostimulation therefore is a confusing nomenclature. Immunoregulation or immunomodulation are other terms used for the same phenomenon, which are as poorly defined as immunostimulation. It is perhaps better understood as the process of maintaining the immune system in a “state of alert” that is capable of efficiently handling microbial infections.1 This is precisely the objective that is desired to handle the invading organisms.

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