0
Clinical Investigations: BRONCHOGENIC CANCER |

Soluble Receptor-Binding Cancer Antigen Expressed on SiSo Cells in Pleural Fluid*: A Potential Diagnostic Marker for Malignant Pleural Effusion

Keisuke Aoe, MD, PhD; Akio Hiraki, MD, PhD; Tadashi Maeda, MD, PhD; Tomoyuki Murakami, MD, PhD; Koichi Yamazaki, MD, PhD; Kazuro Sugi, MD, PhD; Hiroyasu Takeyama, MD, PhD
Author and Funding Information

*From the Departments of Respiratory Medicine (Drs. Aoe, Hiraki, Maeda, and Takeyama) and Clinical Research (Drs. Murakami and Sugi), National Sanyo Hospital, Respiratory Disease Center, Yamaguchi, Japan; and the First Department of Medicine (Dr. Yamazaki), Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Correspondence to: Keisuke Aoe, MD, PhD, Department of Respiratory Medicine and Clinical Research, National Sanyo Hospital, Respiratory Disease Center, 685 Higashi-kiwa, Ube, Yamaguchi 755-0241, Japan; e-mail: keisukeaoe@mtf.biglobe.ne.jp



Chest. 2004;126(4):1195-1197. doi:10.1378/chest.126.4.1195
Text Size: A A A
Published online

Background: We sought a marker to differentiate malignant from nonmalignant pleural effusions.

Methods: We studied 41 patients presenting with pleural effusions to the National Sanyo Hospital between April 2000 and January 2002 (33 men and 8 women; mean age, 68 years). Twenty patients (49%) were proven to have malignant pleural effusions, while 21 patients (51%) had nonmalignant pleural effusions. Thoracentesis was performed.

Results: The mean (± SD) concentration of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) in malignant pleural effusions, measured by enzyme-linked immunosorbent assay, was significantly higher than that in nonmalignant pleural effusions (15.1 ± 33.6 vs 1.4 ± 0.81 U/mL, respectively; p < 0.05).

Conclusion: The determination of the RCAS1 concentration in pleural fluid is informative in the diagnosis of malignant pleural effusions.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543