Nine of 17 brain tumor survivors (53%) have died of pulmonary fibrosis. Two survivors (12%) died within the first 3 years after undergoing chemotherapy, four more died between 6 and 13 years after treatment, and another three have died since then (ie, 13 to 25 years after treatment). Patients who were treated at an earlier age seemed to be at greater risk of developing pulmonary fibrosis. Of the eight patients still alive, we have follow-up data for seven, and they all have radiologic and physiologic (ie, lung function) evidence of upper zone pulmonary fibrosis. These patients have been followed up with serial lung function data at the North West Lung Centre at Wythenshawe Hospital, as presented in Figure 1
(which includes the lung function data of two other patients who received follow-up treatment and survived the first 13 years following treatment but have died since then). Three of the patients have had stable lung function for > 2 decades, but the rest have slowly progressive restrictive defects.